Immune response and innervation signatures in aseptic hip implant loosening
نویسندگان
چکیده
منابع مشابه
Risk Factors for Aseptic Loosening Following Total Hip Arthroplasty
Total hip arthroplasty (THA) is one of the most successful orthopaedic procedures and has relieved pain and improved hip function in millions of patients worldwide. Despite the success of modern prosthetic designs and bearing surfaces, around 10% of THA prostheses still fail within 10 years1. Improvements in surgical technique and prosthesis design have decreased the incidence of deep sepsis, d...
متن کاملOccult Infection in Aseptic Joint Loosening and the Diagnostic Role of Implant Sonication
Our aim was to determine the incidence of occult infection and to examine the role of ultrasound sonication of the implants in cases of presumed aseptic loosening in a prospective trial. Joint swabs, aspirates, and deep tissue samples were obtained from around the prosthesis for routine microbiology. Each prosthesis was sonicated and the sonicate examined with Gram staining and extended culture...
متن کاملThe relationship between cup design and the radiological signs of aseptic loosening in total hip arthroplasty.
We assessed differences in the incidence and appearance of the radiological signs of loosening of the cup for various types of design. This was an observational study based on hip registry data of 15,340 patients with 17,951 total hip arthroplasties collected over a period of 33 years in 49 hospitals in Central Europe. The threaded and the press-fit titanium cups showed significantly less asept...
متن کاملAssociation between Apoptotis and CD4+/CD8+ T-Lymphocyte Ratio in Aseptic Loosening after Total Hip Replacement
Particle-induced osteolysis is a major cause of aseptic loosening after total joint replacement. While the osteolytic cascade initiated by cytokine release from macrophages has been studied extensively, the involvement of T-lymphocytes in this context is controversial and has been addressed by only a few authors. In a former study we detected that the quantity of T-lymphocytes may be influenced...
متن کاملCurrent research in the pathogenesis of aseptic implant loosening associated with particulate wear debris.
Periprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger implant recipients and usually requires surgical revision. Particulate wear debris, continuously generated by articulating motion at the bearing surfaces, has been implicated as one of the primary causes of p...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2016
ISSN: 1479-5876
DOI: 10.1186/s12967-016-0950-5